NFL odds, lines, picks, spreads, best bets, predictions for week 5, 2022: High model on Titans, Jaguars

The Philadelphia Eagles are the only team with an unblemished record entering the NFL’s Week 5 schedule. However, the Eagles will have to keep winning if they are to stay atop the NFC West standings after the Cowboys (3-1) and Giants (3-1) continued their strong start to the season. Philadelphia will travel across the country to face the Arizona Cardinals on Sunday. According to the latest Week 5 NFL odds from Caesars Sportsbook, the Eagles are the five-point favorites on the road, one of the biggest NFL gaps of the week.

Other Notable Weeks 5 NFL Vegas odds include Cowboys vs. Rams (-4.5), Steelers vs. Bills (-14), and Bengals vs. Ravens (-3). What spreads, totals and money lines should you be targeting in your Week 5 NFL betting? All week 5 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting tips and predictions you need to make the best Week 5 NFL picks right now.

The model, which simulates every NFL game 10,000 times, is up nearly $7,000 for players at $100 on top NFL Picks since its creation. The model enters Week 4 of the 2022 NFL season on an incredible 139-103 run on NFL’s top picks that dates back to the 2017 season.

The model has also ranked in the top 10 on NFLPickWatch four of the last six years on NFL direct picks and has beaten more than 94% of CBS Sports Football Pick’em players four times during that time. Anyone who followed him is upstairs.

Now he has turned his attention to the latest NFL odds week 5 and locked in picks for every NFL game. Go here to see all the choices.

Top NFL Week 5 Predictions

One of the model’s strongest NFL Week 5 picks is that the Titans (-2.5) cover against the Commanders in nearly 60% of the simulations. Tennessee is coming off an important 24-17 road win over the Indianapolis Colts although he didn’t score a single point in the second half. Tennessee got off to a flying start behind the running back Derrick Henrywho finished the game with 22 carries for 114 yards and a touchdown.

Henry has now scored a touchdown in three consecutive games. Meanwhile, the Commanders have been disappointing after beating the Jaguars in their first game of the season, losing their last three games. Washington’s defense is giving up 26.8 points per game this season, which ranks 29th overall. Additionally, the Commanders are just 8-16 in their last 24 games at FedEx Field. This is one of the reasons SportsLine’s model predicts the Titans will cover the spread nearly 60% of the time. See which other teams to pick here.

Another one of his Week 5 NFL predictions: The jaguars (-7) cover at home in a division game against Texas. Jacksonville has only played one home game so far, a 24-point shutout win over the Colts. Jacksonville ranks third with a plus-38 point differential, behind arguably the NFL’s top two teams, the Bills and Eagles.

The Jags fell to Philadelphia in Week 4 thanks to wet conditions that resulted in four fumbles lost by Trevor Lawrence. It was certainly a one-game outlier as Lawrence had only three combined fumbles lost in his previous 17 games. The Jags have a top-10 offense and a top-10 defense, while Houston is in the bottom half of the league in both categories. Jacksonville is expected to earn double digits and cover well over 50% of the simulations. The model also has the Under (44.5) which hits well over 50% of the time. See which other teams to pick here.

How to Make Week 5 NFL Picks

The model also made the call on who wins and covers in every other game on the NFL Week 5 schedule, and he also says an underdog causes a huge upset. You can only get every pick for every game on SportsLine.

So what NFL picks can you make with confidence? And which underdog produces a huge upset? Check out the latest NFL odds below, then visit SportsLine to see which teams are winning and cover the spread, all from a proven computer model that has made nearly $7,000 since its inceptionand find out.